Captain Eoin Morgan top-scored with 92 as England beat the World Cup holders for the second time in four days by successfully chasing down a target of 300 with 10 balls to spare to make it 2-2 in the five-match series.
Australia, who won the toss, reached 299-7 thanks to half-centuries from top scorer Glenn Maxwell, who made 85, George Bailey and wicket-keeper Matthew Wade.
But with Morgan leading from the front, England achieved their highest ever successful one-day run chase against Australia.
